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High risk for addiction and dependence. Can cause respiratory distress and death when taken in high doses or when combined with other substances, especially alcohol or other illicit drugs such as heroin or cocaine. Roxicodone abuse symptoms vary by both the individual and the amount taken.Moreover, factors such as body tolerance and frequency of use also play a role. However, common signs and symptoms of Roxicodone can be categorized into disturbances of (1) mood, (2) behavior, (3) psychological functioning, and (4) physical functioning. Here is a look at some of the signs and symptoms.